Neurobiological and behavioral mechanisms of circadian rhythm disruption in bipolar disorder: A critical multidisciplinary literature review and agenda for future research from the ISBD task force on chronobiology
Michael J. McCarthy, John F. Gottlieb, Robert Gonzalez, Colleen A. McClung, Lauren B. Alloy, Sean Cain, Davide Dulcis, Bruno Etain, Benicio N. Frey, Corrado Garbazza, Kyle D. Ketchesin, Dominic Landgraf, Heon-Jeong Lee, Cynthia Marie-Claire, Robin Nusslock, Alessandra Porcu, Richard Porter, Philipp Ritter, Jan Scott, Daniel Smith, Holly A. Swartz, Greg Murray
Symptoms of bipolar disorder (BD) include changes in mood, activity, energy, sleep, and appetite. Since many of these processes are regulated by circadian function, Involvement of disrupted circadian rhythms has been proposed across numerous dimensions of bipolar disorder (BD). The International Society for Bipolar Disorders Chronobiology Task Force (CTF) was commissioned to review evidence for neurobiological and behavioral mechanisms pertinent to BD.
Measuring circadian function in bipolar disorders: Empirical and conceptual review of physiological, actigraphic, and self-report approaches
Greg Murray, John Gottlieb, Maria Paz Hidalgo, Bruno Etain, Philipp Ritter, Debra J. Skene, Corrado Garbazza, Ben Bullock, Kathleen Merikangas, Vadim Zipunnikov, Haochang Shou, Robert Gonzalez, Jan Scott, Pierre A. Geoffroy, Benicio N. Frey
Interest in biological clock pathways in bipolar disorders (BD) continues to grow, but there has yet to be an audit of circadian measurement tools for use in BD research and practice.
Maintaining Daily Routines to Stabilize Mood: Theory, Data, and Potential Intervention for Circadian Consequences of COVID-19
Greg Murray, PhD, John Gottlieb, MD, and Holly A Swartz, MD
The COVID-19 pandemic is expected to trigger a global increase in mental health problems. One of the many pathways by which COVID-19-related social changes might impact mental health involves circadian disruption, the focus of this commentary.
Circadian science and psychiatry: Of planets, proteins and persons
Greg Murray
The aim of this review is to briefly introduce circadian science and highlight three qualities of the approach for psychiatry: circadian biology is well characterised, circadian function has direct clinical relevance and ‘a view from the clock’ aligns with growing calls for complex systems thinking in psychiatry
The chronotherapeutic treatment of bipolar disorders: A systematic review and practice recommendations from the ISBD task force on chronotherapy and chronobiology
John F. Gottlieb, Francesco Benedetti, Pierre A. Geoffroy, Tone E. G. Henriksen, Raymond W. Lam, Greg Murray, James Phelps, Dorothy Sit, Holly A. Swartz, Marie Crowe, Bruno Etain, Ellen Frank, Namni Goel, Bartholomeus C. M. Haarman, Maree Inder,
Håvard Kallestad, Seong Jae Kim, Klaus Martiny, Ybe Meesters, Richard Porter, Rixt F. Riemersma‐van der Lek, Philipp S. Ritter,
Peter F. J. Schulte, Jan Scott 26, Joseph C. Wu, Xin Yu and Shenghao Chen.
A systematic review of the literature on the efficacy and tolerability of the major chronotherapeutic treatments of bipolar disorders (BD)—bright light therapy (LT), dark therapy (DT), treatments utilizing sleep deprivation (SD), melatonergic agonists (MA), interpersonal social rhythm therapy (IPSRT), and cognitive behavioral therapy adapted for BD (CBTI‐BP)—and propose treatment recommendations based on a synthesis of the evidence.
Forecasting the course of bipolar disorder using rest-activity rhythms: Protocol for a multi-study modelling project
Greg Murray, Sandipan Ray, Richard Porter, Fatemeh Hadaeghi, Denny Meyer, Maree Choi, Sara Lapsley, Matthew Tennant, Bridgette Thwaites, Ly Nguyen, Hailey Tremain, Saibal Saha and Jan Scott
Bipolar disorder (BD) is defined by complex, poorly understood mood dynamics. Our current inability to predict significant changes in mood, particularly episode relapses, is one of the most challenging features of BD for patients and clinicians. Research into sleep and circadian rhythm disruption suggests that relapse risk may be measurable in 24-hour rest-activity rhythms (RAR) collected by actigraphy.
Time-restricted eating as an adjunctive intervention for bipolar disorder
Prof Sheri Johnson, Prof Lance Kriegsfeld, Dr Liam Mason, Dr Kenneth Allen, Prof Michael Berk, Dr Keanan Joyner, Prof Greg Murray, Prof Satchidananda Panda, Dr Emily Manoogian, Prof Erin Michalak
Extensive research indicates that sleep and biological rhythms are often disrupted among those with bipolar disorder (BD) and among their relatives, and that these biological rhythms are tied to severity of illness, to cognitive dysfunction, and to metabolic syndromes.